强化化疗期间身体功能的动态变化会影响老年AML成人的移植结果
Gi-June Min1,2, Byung-Sik Cho1,2, Daehun Kwag1,2
1Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Frontiers in oncology
|November 29, 2023
概括
强化化疗对老年AML患者的老年评估产生影响. 移植前改善的身体功能预示着更好的生存率,而持续的损伤表明更糟糕的结果.
科学领域:
- 老年医学 老年医学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 密集化疗 (IC) 对患有急性髓性白血病 (AML) 的老年人影响老年评估 (GA) 领域.
- 关于这些GA变化如何影响移植结果的数据有限.
研究的目的:
- 在老年AML患者的诊断和全源造血干细胞移植 (allo-HSCT) 之前,对GA域的预后作用进行前性评估.
- 检查身体,认知,心理和营养功能的动态变化,以及社会支持.
主要方法:
- 对51名AML患者 (≥60岁) 的前性研究,在IC后实现完全缓解.
- 基线和预合金HSCT GA,包括短物理性能电池 (SPPB).
主要成果:
- GA领域显示动态变化;社会支持的显著转变,自我报告的身体/心理功能和痛苦.
- 诊断时身体功能差,但不是移植前,预测生存率较低.
- 移植前改善的身体功能与更长的生存时间相关;持续的SPPB损伤强烈预测了更糟糕的结果.
结论:
- 在AML患者中,IC诱导动态GA变化.
- 客观测量的身体功能变化可以预测移植结果.
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