尿道和肠道微生物组与膀癌有关吗?
Joanna Chorbińska1, Wojciech Krajewski1, Łukasz Nowak1
1Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, Wrocław, Poland.
Clinical Medicine Insights. Oncology
|November 29, 2023
概括
膀癌患者的尿路和肠道微生物组与健康个体没有显著差异. 然而,膀癌患者的微生物组合因性别而异.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 微生物组失生症与泌尿病的病原发生有关,包括膀癌 (BC).
- 了解BC的尿路和肠道微生物群对于疾病管理至关重要.
研究的目的:
- 将膀癌 (BC) 患者的尿路和肠道微生物群与健康的对照组 (HC) 进行比较.
- 调查微生物组成和多样性的潜在差异.
主要方法:
- 在BC患者和HC患者的尿液和便样本上进行了16S rRNA基因测序.
- 在经尿道切除膀瘤之前收集了样本.
主要成果:
- 在BC患者和HC患者之间,在尿液或便中没有观察到α和β多样性的显著差异.
- 特定的微生物种群在尿液 (例如,乳酸菌,霍华德菌,性菌) 和便 (例如,Desulfobacterota,Alphaproteobacteria) 中显示出差异的丰度,基于患者的特征,如BCG治疗史和性别.
- 在BC患者中的微生物组组成因患者的性别而异.
结论:
- 膀癌患者的尿道和肠道微生物组的整体组成与健康对照组没有显著差异.
- 性别是影响膀癌患者尿道和肠道微生物组合的重要因素.
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