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作为PPARα激动剂,纤维酸预防手术后认知功能障碍,通过增强小鼠脂肪酸氧化

Tiantian Liu^1,2,3,4, Xinlu Chen^1,2,3,4, Ziqi Wei^2,3,4

¹Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing 210008, China.

Translational neuroscience

|November 29, 2023

概括

费诺纤维酸 (FF) 是一种PPARα激动剂,通过增强脂肪酸氧化来防止麻醉诱导的术后认知功能障碍 (POCD). 这项研究证明了FFFF.

科学领域:

神经科学是一个神经科学.
代谢过程中的代谢.
麻醉学麻醉学

背景情况:

手术后认知功能障碍 (POCD) 是一个重要的临床问题,发病率和残疾率很高.
脂肪酸氧化中的障碍与POCD的病理生理学有关.
过氧体增殖器激活受体α (PPARα) 调节脂肪酸氧化和线粒体脂肪酸转移.

研究的目的:

为了调查PPARα激动剂纤维酸 (FF) 是否可以预防长期异黄麻醉诱导的POCD.
探索脂肪酸氧化在FF对POCD的保护作用中的作用.

主要方法:

在C57BL/6J小鼠和N2a细胞中使用6小时异氨酸麻醉建立了POCD模型.
在麻醉前使用FF的预处理细胞和小鼠,评估脂肪酸氧化和认知功能.
利用西式涂抹来确定与脂肪酸氧化相关的蛋白质水平和记忆评估的情境恐惧条件.

主要成果:

在老鼠海马和N2a细胞中,长期的异类麻醉诱导了记忆缺陷和与脂肪酸氧化相关的蛋白质 (PPARγ 协活性剂1α,CPT1A,PPARα) 的降低.
在小鼠中,FF预处理可提高这些蛋白质的调节,并保护它们免受认知损伤.
用Etomoxir阻断脂肪酸氧化消除了FF的保护作用,证实了该机制.

结论:

费诺纤维酸 (FF) 是一种PPARα激动剂,可以预防长期异花麻醉诱导的POCD.
这种保护是通过增强脂肪酸氧化来实现的.
准PPARα和脂肪酸氧化是一种POCD的潜在治疗策略.

关键词:

这是一种PPARα.脂肪酸氧化过程中的脂肪酸氧化.芬诺纤维酸盐的使用方法这是oflurane的.术后认知功能障碍术后认知功能障碍

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