暴露调查工具 (LEST):一种方法方法来突出看不见的中毒
Waleed S Al Sukaiti1,2,3, Mohammed Abdullah Al Shuhoumi4,5,6, Hassan I Al Balushi2,3,7,8
1Department of Emergency Medicine, Ibri Regional Hospital, MOH, Oman.
MethodsX
|November 29, 2023
概括
慢性暴露是一个重要的公共卫生问题,特别是在中东和北非 (MENA). 研究人员开发了暴露调查工具 (LEST),用于早期检测和预防中毒.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 是一种无处不在的重金属,广泛分布在环境中.
- 虽然富裕国家急性暴露已经减少,但慢性暴露仍然是一个重大的公共卫生危险,特别是在中东和北非 (MENA) 等发展中国家.
- 目前用于检测中毒的现有方法不足,强调需要改进诊断工具.
研究的目的:
- 为了解决缺乏一个全面的工具来检测中东和北非地区的暴露.
- 开发和验证一个根据中东和北非国家的社会文化背景量身定制的暴露调查工具.
- 加强早期检测,促进进一步的研究,并支持实施暴露预防策略.
主要方法:
- 在PubMed和Scopus数据库 (1981-2018) 中进行了系统的文献搜索.
- 德尔菲法用于确定污染源.
- 混合方法评估工具 (MMAT) 和SIGN & GRADE标准用于质量评估和证据评估.
主要成果:
- 该研究确定了14种类型和82种子类型的污染物.
- 开发了一种新型工具,暴露调查工具 (LEST),将血液中的含量,环境数据和人口统计信息整合起来.
- LEST旨在识别有中毒风险的个体,考虑当地社会文化因素.
结论:
- 暴露调查工具 (LEST) 在打击中毒方面取得了重大进展.
- LEST提供了一种强大,多方面的方法,以改善早期检测和预防暴露.
- 这种工具有可能改善全球高风险人群的健康状况,首先是MENA地区.
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