Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Amino acids03:42

Amino acids

89.0K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible...
89.0K
Leaky Scanning02:28

Leaky Scanning

5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Acid Halides to Amides: Aminolysis01:07

Acid Halides to Amides: Aminolysis

2.8K
Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
2.8K
Protein Organization01:13

Protein Organization

138.0K
Overview
138.0K
tRNA Activation02:26

tRNA Activation

19.3K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
19.3K
Mass Spectrometry of Amines01:19

Mass Spectrometry of Amines

4.2K
In mass spectroscopy, amines undergo fragmentation to give parent ions with odd molecule weights. This observed mass spectrum follows the nitrogen rule: a molecule with an odd number of nitrogen atoms produces a parent ion with an odd molecular weight. The remaining fragments have an even mass.
Amines undergo fragmentation through α cleavage, producing nitrogen-containing cations—iminium ions—and alkyl radicals. Mass spectra of aromatic and cyclic aliphatic amines exhibit...
4.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

AIEdit: Alignment-free genome assembly polisher trained on spaced seed match patterns.

PLoS computational biology·2026
Same author

ntStat: k-mer characterization using occurrence statistics in raw sequencing data.

PLoS computational biology·2026
Same author

A comprehensive tandem repeat catalog of the human genome.

Nature communications·2026
Same author

ntRoot: computational inference of human ancestry at scale from genomic data.

Bioinformatics advances·2025
Same author

Streaming Long-Read Sequence Alignments for HLA Predictions Using HLAminer.

Current protocols·2025
Same author

Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation.

Genome research·2024
Same journal

Region-aware bridge modeling enables interpretable mesoscale representation of spatial transcriptomic tissue sections.

Bioinformatics advances·2026
Same journal

Microbiome differential abundance methodologies to detect relevant taxa associated with chemotherapy toxicity rate in colorectal cancer.

Bioinformatics advances·2026
Same journal

maldipickr dereplicates microbial MALDI-TOF spectra to facilitate multiplexed isolation.

Bioinformatics advances·2026
Same journal

RAM-MSA: an anytime memory-bounded method for exact multiple sequence alignment using path finding.

Bioinformatics advances·2026
Same journal

Interpretable machine learning for low-sample multi-omics: a case study of ferret vaccine response.

Bioinformatics advances·2026
Same journal

DeepTaxa: a hybrid CNN-BERT framework for 16S rRNA taxonomic classification.

Bioinformatics advances·2026
查看所有相关文章

相关实验视频

Updated: Jul 9, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.4K

aaHash:递归氨基酸序列的哈希处理

Johnathan Wong1, Parham Kazemi1, Lauren Coombe1

  • 1Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 4S6, Canada.

Bioinformatics advances
|November 29, 2023
PubMed
概括
此摘要是机器生成的。

一个新的哈希算法,aaHash,加速生物信息学对蛋白质序列的分析超过10倍. 这种特定领域的方法可以解释生化相似性,提高k-mer哈希的速度和灵敏度.

更多相关视频

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.7K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.3K

相关实验视频

Last Updated: Jul 9, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.4K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.7K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.3K

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • 对于生物信息学而言,K-mer散列是至关重要的,但对于生物序列而言,通用算法是低效的.
  • 现有的方法无法利用氨基酸序列的特定字母和生物化学特性.
  • 需要特定域的散列算法来增强蛋白质序列分析.

研究的目的:

  • 开发一个针对氨基酸序列优化的新哈希算法.
  • 提高蛋白质数据的生物信息学应用的速度和灵敏度.
  • 在蛋白质序列的背景下解决通用字符串散列的局限性.

主要方法:

  • 介绍aHash,一个专门为氨基酸序列设计的递归哈希算法.
  • aaHash采用多个哈希级别来捕获氨基酸之间的生物化学相似性.
  • 该算法在k-mer散列中实现并对其性能进行评估.

主要成果:

  • aaHash表现出了显著的速度改进,对相邻的k-mers.执行速度比通用字符串哈希算法快大约10倍.
  • 该算法有效地利用氨基酸的生物化学特性,以实现更高效的哈希处理.
  • 这导致了蛋白质序列的加速和潜在更敏感的分析.

结论:

  • aaHash在蛋白质序列分析中为k-mer哈希提供了显著的性能提升.
  • aaHash的特定域方法通过考虑氨基酸的生物化学性质,改进了通用的哈希方法.
  • 这种工具有可能加速和完善处理蛋白质序列的各种生物信息学应用.