肝细胞癌免疫治疗新兴生物标志物的现状和挑战 (综述)
Mo Cheng1, Xiufeng Zheng1, Jing Wei1
1Department of Medical Oncology, Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Experimental and therapeutic medicine
|November 29, 2023
概括
肝细胞癌 (HCC) 治疗正在通过免疫疗法推进. 像PD-1/PD-L1这样的生物标志物对于识别将从这些创新疗法中受益的患者至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 肝细胞癌 (HCC) 是一种主要的肝癌,晚期预后不佳.
- 目前的治疗方法包括手术,切除,化疗和免疫治疗.
研究的目的:
- 审查目前在HCC中免疫治疗的生物标志物.
- 讨论利用这些生物标志物用于精准医学的挑战.
主要方法:
- 对HCC的免疫疗法生物标志物的文献综述.
- 对PD-1/PD-L1,瘤突变负担和循环瘤DNA等生物标志物的分析.
主要成果:
- 免疫疗法是高级HCC的关键策略.
- 生物标志物对于免疫治疗中患者选择至关重要.
- PD-1/PD-L1,瘤突变负担和ctDNA是有前途的生物标志物.
结论:
- 生物标志物对于HCC免疫疗法的有效应用至关重要.
- 需要进行进一步的研究,以克服针对个性化HCC治疗生物标志物利用的挑战.
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