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在甲状腺淋巴结剖析转移性结直肠癌的预后因素的多中心研究
Jun Woo Bong1, Sanghee Kang1, Pyoungjae Park1
1Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Annals of surgical treatment and research
|November 29, 2023
概括
在结肠直肠癌 (CRC) 中,准大动脉淋巴结解剖 (PALND) 显示了孤立转移的有利生存率. 然而,预后因素,如准大动脉淋巴结转移严重性因素 (PALNM-SFs),对于评估PALND后的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 与其他转移部位相比,对远程转移的结直肠癌 (CRC) 中对准大动脉淋巴结解剖 (PALND) 的作用仍然不太了解.
- 评估CRC中PALND手术结果和预后因素对于改善患者管理至关重要.
研究的目的:
- 在患有结直肠癌 (CRC) 和甲状腺淋巴结转移 (PALNM) 的患者中,评估关节淋巴结解剖 (PALND) 后的手术结果.
- 确定影响CRC患者在PALND后生存的预后因素.
主要方法:
- 对接受PALND进行PALNM的患者的医疗记录的回顾性审查.
- 将患者分为M1a (孤立的PALNM) 和M1bc (其他远程转移) 组.
- 定义和评估三种准大动脉淋巴结转移严重性因子 (PALNM-SFs) 对其对生存的影响.
主要成果:
- 与M1bc组 (6.4%) 相比,M1a组的5年整体存活率 (OS) 显著更高 (61.1%) .
- 患有两种或多种PALNM-SF的患者的生存状况比患有1种PALNM-SF的患者更差.
- 在多变量分析中,非隔离的PALNM (M1bc) 和两个或两个以上的PALNM-SF是生存的显著负预后因素.
结论:
- 帕伦德可以为结直肠癌患者提供有利的生存结果,这些患者患有孤立的偏大动脉淋巴结转移.
- 对于非隔离的甲状腺淋巴结转移而言,PALND的实用性需要进一步研究.
- 甲状腺淋巴结转移严重性因子 (PALNM-SFs) 是评估CRC中PALND后预后的有价值工具.
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