识别非传统的小分子降解剂和稳定剂的烯合成酶的识别

Joseph G F Hoock1, Cecilia Rossetti1, Mesut Bilgin2

  • 1Department of Chemistry, Technical University of Denmark Kemitorvet 207 Kongens Lyngby 2800 Denmark luclar@kemi.dtu.dk.

Chemical science
|November 29, 2023
PubMed
概括

研究人员开发了新的化学工具来降解烯合成酶 (SQS),这是一个对胆固醇合成至关重要的酶. 这种向蛋白质降解方法成功降低了细胞胆固醇,提供了新的治疗策略.

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