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优化可离子化脂质用于可气溶性mRNA脂质纳米颗粒的优化

Mae M Lewis1, Melissa R Soto2, Esther Y Maier3

  • 1Department of Biomedical Engineering The University of Texas at Austin Austin Texas USA.

Bioengineering & translational medicine
|November 29, 2023
PubMed
概括

新的mRNA脂质纳米粒子 (LNPs) 配制SM-102显示出改善的稳定性和针对性传递用于肺部应用. 这一突破增强了对囊性纤维化等肺部疾病的潜在mRNA疗法.

关键词:
气溶化是一种空气化方法.可离子化脂质的离子化脂质脂质纳米颗粒是一种纳米粒子.它们是mRNARNA.肺部输送是通过肺部进行的.

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