基因工程纳米梅利丁囊泡用于多模式协同癌症治疗
Jianzhong Zhang1,2, Xue Liu1,2,3, Yutian Xia1,2
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health Xiamen University Xiamen China.
Bioengineering & translational medicine
|November 29, 2023
概括
一个新的囊泡抗体-梅利丁 (VAM) 平台提供向的癌症治疗. 这种药物输送系统减少了梅利丁的毒性,并增强了联合治疗的协同治疗效果.
科学领域:
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
- 在瘤学瘤学.
背景情况:
- 蜜蜂毒素的成分梅利丁 (Melittin) 对癌症治疗有前途,但面临着血液溶解和细胞毒性等局限性.
- 开发有针对性的输送系统对于克服梅利丁临床应用障碍至关重要.
研究的目的:
- 开发和验证一种新的基因工程囊泡抗体-梅利丁 (VAM) 药物输送平台,用于向的癌症联合治疗.
- 为了减少非目标毒性,并提高基于梅利的癌症治疗的疗效.
主要方法:
- 使用细胞等离子膜制造VAM,在膜上显示生物合成的重组蛋白 (hGC33 scFv-melittin).
- 在瘤部位由hGC33 scFv结合的纳米利丁的MMP14反应释放.
- 用小分子药物 (doxorubicin) 和纳米粒子 (purpurin 18) 加载VAM用于组合治疗.
主要成果:
- VAM成功地降低了梅利丁的血液溶解活性和非目标毒性.
- 通过VAM同时提供抗癌药物,增强了瘤透率,并证明了协同治疗效应.
- 声动疗进一步改善了纳米利丁的免疫调节作用,激活了免疫反应.
结论:
- 基于VAM的策略为多模式协同癌症治疗提供了通用和有前途的方法.
- VAM平台证明了针对性和组合癌症治疗的临床可转化性.
- 这种新的输送系统有效地克服了梅利丁的局限性,为改进的癌症疗法铺平了道路.
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529