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多态纳米体晶体作为长期作用的玻璃内疗法,用于湿时与年龄相关的黄斑变性

Shuqian Zhu¹, Shilong Fan², Tianxin Tang¹

¹School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Tsinghua University Beijing People's Republic of China.

Bioengineering & translational medicine

|November 29, 2023

概括

新的蛋白质晶体提供了一种有前途的策略,用于治疗湿时与年龄相关的黄斑变性 (湿时AMD),通过减少对抗血管内皮生长因子 (VEGF) 治疗的静脉内注射.

科学领域:

眼科医生眼科眼科
生物技术是生物技术.
材料科学材料科学材料科学

背景情况:

湿性黄斑变性 (湿性AMD) 是导致失明的主要原因.
目前的治疗包括频繁的血管内皮生长因子 (VEGF) 蛋白质的静脉内注射.
创新的驱动因素是需要更少的侵入性和更长时间的治疗策略.

研究的目的:

设计具有不同结晶性质的抗VEGF纳米体.
为了研究晶格结构对蛋白质释放率的影响.
探索用于慢性湿性AMD治疗的新型药物输送系统.

主要方法:

在模型抗VEGF纳米体上的表面残留的合理工程.
纳米体结晶倾向和晶格结构的表征.
分析不同多态晶体形式的蛋白质释放动力学,包括协调晶体.

主要成果:

获得了具有相同结构和结合亲和力但具有不同的晶体特性的抗VEGF纳米体.
与P1晶格相比,确定了一个更密集的P212121晶格,其蛋白质释放速度较慢.
证明将协调纳入进一步降低了蛋白质释放率.

结论:

纳米体晶体中的蛋白质多态化为控制药物输送提供了一个可行的策略.
工程化多态蛋白质晶体可以促进反VEGF蛋白质的缓慢,持续的释放.
这种方法有可能开发出改善的,较少频繁的湿 AMD 内注射疗法.

关键词:

晶体悬浮液是一种晶体悬浮液.纳米体是一个纳米体.热力学特性热力学特性湿 AMD 湿 AMD 的时间

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