儿童恶性瘤的CAR-T细胞:过去,现在,未来和护理方面的影响
Colleen Callahan1, Lauren Haas1, Laura Smith1
1Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, USA.
Asia-Pacific journal of oncology nursing
|November 29, 2023
概括
化学抗原受体-T (CAR-T) 细胞疗法改变了儿科B细胞急性淋巴细胞白血病 (ALL) 治疗. 这种疗法目前正在探索其他儿童癌症,强调安全实践和护理.
科学领域:
- 儿科瘤学 儿科瘤学
- 免疫治疗是一种免疫疗法.
- 血液学恶性瘤是什么
背景情况:
- 儿科癌症的治疗,特别是复发性/耐药性B细胞急性淋巴细胞白血病 (ALL),已经被奇米尔抗原受体-T (CAR-T) 细胞疗法的出现彻底改变.
- 在B细胞ALL中CAR-T细胞疗法的成功刺激了对其在更广泛的儿科恶性瘤的有效性进行研究.
研究的目的:
- 审查CAR-T细胞治疗在儿科B细胞ALL中的引入和演变.
- 探索其他儿科癌症中CAR-T细胞疗法的正在进行和未来的临床试验.
- 突出护理在管理CAR-T细胞治疗毒性和确保患者安全方面的关键作用.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 包括第一手机构经验.
- 分析当前和过去的临床试验数据.
主要成果:
- CAR-T细胞疗法显著改变了儿科B细胞ALL复发/耐药性治疗模式.
- 临床试验正在将CAR-T细胞治疗应用扩展到各种其他儿科恶性瘤.
- 严重毒性的有效管理需要警监测和遵守安全协议.
结论:
- 卡特-T细胞疗法代表了儿科瘤学的重大进步,特别是在B细胞ALL.
- 在其他儿科癌症中,CAR-T细胞治疗的潜力需要进一步研究.
- 强大的护理教育和参与对于优化患者的治疗结果和管理CAR-T细胞治疗的复杂性至关重要.
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