口腔炎症负荷与精液和精子功能分析之间的关联:一个横截面研究
Reza Pourabbas1,2, Samin Farajzadeh1, Amirreza Babaloo1
1Department of Periodontology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of dental research, dental clinics, dental prospects
|November 29, 2023
概括
通过口腔多态核中性粒细胞 (oPMN) 数量测量口腔炎症的升高与精子运动性降低和形态异常有关. 更高的oPMN水平也与精子DNA碎片化增加相关,影响男性生育能力.
科学领域:
- 生殖生物学和免疫学
- 口腔健康和全身性疾病之间的联系
背景情况:
- 牙周炎与男性生育能力的降低有关,炎症可能会调解这种联系.
- 口服炎症负荷 (OIL) 可以通过口服多态核中性粒细胞 (oPMN) 数量来量化,反映牙周病的严重程度.
研究的目的:
- 为了研究OIL之间的相关性,通过oPMN计数表示,和精子细胞的关键功能参数.
主要方法:
- 这是一项涉及229名志愿者的横截面研究.
- 分析口腔冲洗和精液样本的oPMN,精液多态核 (sPMNs),精子度,精子总数,运动性,形态和精子DNA碎片化指数 (SDFi).
- 使用多重线性回归来评估oPMN和精液参数之间的关系.
主要成果:
- 增加的oPMN数量与精子运动 (P<0.001) 和正常的精子形态 (P<0.001) 有显著的反相关性.
- oPMN计数与sPMN计数 (P<0.001) 和精子DNA碎片化指数 (SDFi) (P<0.001) 正相关.
- 在oPMN数量和精子度之间没有发现显著的关联.
结论:
- 口腔炎症负荷,如oPMN计数所示,可能会对男性生育能力产生负面影响.
- 增加的oPMN水平与精子运动性降低,精子形态异常,sPMN数量增加和SDFi增加有关.
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