肝硬化患者左心室透静功能障碍的病例-队列研究:肝心轴:肝心轴
Rushil Solanki1, Srijaya Sreesh1, Thomas Varghese Attumalil2
1Department of Gastroenterology, Government Medical College, Thiruvananthapuram, Kerala (Rushil Solanki, Srijaya Sreesh, Shivabrata dhal Mohapatra, Vijay Narayanan, Devika Madhu, Avisek Chakravorty, Ravindra Pal, Krishnadas Devadas).
Annals of gastroenterology
|November 29, 2023
概括
肝硬化患者的左心室扩张功能障碍 (LVDD) 与疾病严重程度和并发症有关. 酸性流体蛋白质水平可能预测LVDD,表明生存结果较差.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 左心室扩张性功能障碍 (LVDD) 是肝硬化心肌病的早期指标.
- 肝硬化患者中LVDD的临床意义需要进一步调查.
- 这项研究研究了LVDD与肝硬化严重程度,并发症和存活率之间的关联.
研究的目的:
- 评估LVDD在肝硬化患者中的临床意义.
- 为了确定与肝硬化中LVDD相关的因素.
- 评估LVDD对肝硬化患者存活时间的影响.
主要方法:
- 203名肝硬化患者接受了2D心声扫描与组织多普勒成像.
- 139名患有LVDD的患者与64名没有LVDD的对照患者进行了比较.
- 使用了后勤回归和卡普兰-梅尔分析.
主要成果:
- LVDD与更高的儿童-图尔科特-普格 (CTP) 类C,MELD分数,,肝脑病和肝综合征显著相关.
- 与非酒精性脂肪肝炎 (NASH) 相关的肝硬化与LVDD的相关性更强.
- 多变量分析确定了较高的CTP得分,性流体蛋白质和延长的QTc间隔作为LVDD的独立预测因素.
结论:
- 较高的CTP得分,延长的QTc和升高的性流体蛋白与肝硬化中的LVDD显著相关.
- 酸性流体蛋白>1g/dL可以作为评估LVDD的预测指标.
- 在肝硬化患者中,LVDD与较差的生存结果有关.
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