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低老年营养风险指数作为免疫检查点抑制剂治疗固体癌症的不良预后生物标志物

Lilong Zhang¹, Kunpeng Wang¹, Tianrui Kuang¹

¹Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

Frontiers in nutrition

|November 29, 2023

概括

老年营养风险指数 (GNRI) 可以预测癌症患者的免疫治疗反应. 低GNRI水平与接受免疫治疗的癌症患者的生存结果较差和反应率较低有关.

科学领域:

在瘤学瘤学.
营养科学营养科学
医学统计医学统计

背景情况:

营养不良是癌症患者的一个重大问题,可能会影响治疗疗效.
老年营养风险指数 (GNRI) 是评估营养状况的有效工具.

研究的目的:

评估老年营养风险指数 (GNRI) 作为癌症患者免疫治疗反应的预测指标.
分析GNRI定义的营养不良与临床结果 (如整体存活期 (OS) 和无进展存活期 (PFS)) 之间的关联.

主要方法:

在PubMed,Cochrane图书馆,EMBASE和谷歌学者中进行了系统的文献搜索,直到2023年7月.
11项研究的元分析,包括1417名癌症患者.
评估的结果包括OS,PFS,客观反应率 (ORR) 和疾病控制率 (DCR).

主要成果:

癌症患者的低GNRI水平显示显著较短的OS (HR: 2.64) 和PFS (HR: 1.87).
较低的客观应答率 (OR:0.46) 和疾病控制率 (OR:0.42) 在低GNRI患者中观察到.
敏感性分析证实了这些发现的稳定性,并使用Egger和Begg的测试来评估出版偏差.

结论:

老年营养风险指数 (GNRI) 作为癌症患者免疫治疗反应的有价值的预测标记.
正如GNRI指出的营养状况,在接受免疫治疗的癌症患者的治疗结果中起着至关重要的作用.

关键词:

生物标志物生物标志物癌症癌症癌症癌症老年人的营养风险指数.免疫检查点抑制剂免疫检查点抑制剂结果就是结果.

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