伊朗一家大型转诊医院的重症监护病房中的抗生素耐药性模式
Samaneh Salarvan1, Alireza Abdollahi1, Pegah Afarinesh Khaki2
1Department of Pathology, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iranian journal of pathology
|November 29, 2023
概括
多抗药性 (MDR) 感染是重症监护室 (ICU) 的一个主要问题. 这项研究发现,在伊朗的ICU中,抗生素耐药性和MDR的高率,突显了对修订抗菌素处方实践的迫切需要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 抗生素耐药性,特别是多重耐药性 (MDR),构成了全球健康的重大威胁.
- 重症监护病房 (ICU) 是关键的环境,在这些环境中,MDR感染的患病率往往很高.
- 了解局部耐药性模式对于有效的治疗策略至关重要.
研究的目的:
- 调查ICU患者中抗生素耐药性和MDR的流行率和模式.
- 在一个主要的伊朗转诊中心确定常见的微生物菌株及其易感性概况.
主要方法:
- 从1755名ICU患者的血液样本进行培养和分析.
- 使用尔-基尔比磁盘扩散方法进行了抗菌素敏感性测试.
- 确定了特定耐药微生物菌株的流行率和对各种抗生素的耐药率.
主要成果:
- 总体抗生素耐药率为85.9%,MDR率为96.3%.
- 最常被隔离的病原体是 *Klebsiella pneumoniae* (22.1%) 和凝结酶阴性 *Staphylococcus* (15.0%).
- 观察到对科特里莫克萨 (61.7%),西普罗夫洛克萨 (51.3%),伊米佩内姆 (50.0%) 和安皮西林 (49.6%) 的高耐药性.
结论:
- 伊朗ICU表现出令人担忧的抗生素耐药性和MDR的高水平.
- 迫切需要重新评估和修改ICU设置中的抗菌素处方和管理策略.
- 对局部耐药性模式的监测对于指导实证抗生素治疗至关重要.
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