与 Prurigo Nodularis 相关的事件并发症,资源使用和因任何原因的死亡率:英国的回顾性数据库分析
Christopher Ll Morgan1, Melissa Thomas1, Benjamin R Heywood1
1Pharmatelligence, Cardiff, United Kingdom.
JID innovations : skin science from molecules to population health
|November 29, 2023
概括
患有结节炎 (PN) 的患者经历了显著更高的伴随性疾病比率,如亚托皮炎和抑郁症. 这种慢性皮肤疾病还导致医疗资源利用率增加和死亡风险更高.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 卫生经济学 卫生经济学
背景情况:
- 结膜炎 (PN) 是一种慢性炎症性皮肤疾病.
- 了解相关的并发症,医疗保健资源利用率和死亡率对于患者管理和医疗保健规划至关重要.
研究的目的:
- 调查诊断出prurigo nodularis的患者患病率,医疗资源利用模式和死亡风险.
- 将这些结果与匹配的对照组进行比较.
主要方法:
- 一个回顾性队列研究,使用临床实践研究数据链接 (CPRD) 数据库.
- 确定了发生性prurigo nodularis (2008-2018) 病例,并与对照进行了匹配.
- 分析包括伴随性疾病的相对风险 (RR) 和后续风险和死亡率的危险比率 (HR),以及资源利用率和成本比率的发病率比率 (IRR).
主要成果:
- 患有PN的患者显示,阿托皮性皮炎 (RR=2.57),抑郁症 (RR=1.71),焦虑症 (RR=1.54),冠状动脉心脏病 (RR=1.58),慢性病 (RR=1.53) 和2型糖尿病 (RR=1.84) 的患病率显著更高.
- 观察到阿托皮性皮炎 (HR=6.58),抑郁症 (HR=1.61) 和冠状动脉心脏病 (HR=1.37) 的风险增加.
- 在初级保健 (IRR=1.48),住院 (IRR=1.80),门诊 (IRR=2.15) 和A&E (IRR=1.32) 设置中,医疗保健资源利用率较高,相关成本更高.
- 整体死亡风险显著增加 (HR=1.37).
结论:
- 结膜炎与大量的并发疾病负担,医疗保健资源利用率的增加和死亡风险的增加有关.
- 这些发现强调了PN的系统影响,并强调了需要全面的患者护理策略.
- 进一步研究PN及其相关条件的潜在机制和有效管理是有必要的.
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