晚期黑色素瘤患者接受免疫治疗的皮肤和非皮肤不良影响
Howa Yeung1,2, Krittin J Supapannachart3, Sandy Francois1
1Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA.
JID innovations : skin science from molecules to population health
|November 29, 2023
概括
在黑色素瘤免疫治疗患者中,皮肤不良反应 (CAE) 如皮疹或与非皮肤不良反应 (NCAE) 的更高可能性有关. 早期发现NCAE可能会改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 黑色素瘤免疫疗法可以引起皮肤不良反应 (CAE) 和非皮肤不良反应 (NCAE).
- 了解CAE和NCAE之间的关系可能会揭示潜在免疫路径的洞察力.
- 识别关联可以为免疫治疗副作用的临床管理提供信息.
研究的目的:
- 在接受免疫治疗的晚期黑色素瘤患者中,研究CAE (皮疹,) 和NCAE之间的关联.
- 确定CAE的存在是否预测NCAE的发展.
主要方法:
- 对34名III-IV阶段黑色素瘤患者进行免疫治疗的前性队列研究.
- 电子医疗记录从第一次输液到1年的不良事件进行了审查.
- 统计分析,包括赔率比率 (ORs),比较CAE和NCAE发展.
主要成果:
- 38.2%的患者发生了CAE和NCAE.
- 皮肤不良反应与非皮肤不良反应的更高几率显著相关 (OR = 9.72).
- 在患有CAE的患者中,NCAE的中位数发病时间较短 (63天),与没有CAE的患者相比 (168天).
结论:
- 皮肤不良反应与黑色素瘤免疫治疗中非皮肤不良反应的风险增加有关.
- 早期识别和管理CAE可能有助于预测和潜在地减轻NCAE.
- 需要进行更大规模的研究来证实这些关联,并为临床实践提供信息.
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