疹带外围神经并发症:它们在脊髓和神经根中的病理生理学
Hiroshi Shoji1, Kouki Matsuo1, Tomonaga Matsushita2
1Division of Neurology, St. Mary's Hospital, Kurume, Fukuoka, Japan.
Intractable & rare diseases research
|November 29, 2023
概括
疹病毒 (VZV) 的重新激活会导致疹病毒 (HZ) 和罕见的神经病变. 这项研究确定了HZ外围神经病变中的四种VZV传播模式,有助于临床意识.
科学领域:
- 神经学 神经学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 腹病毒 (Varicella zoster virus,VZV) 引起水,并在脊柱背部根结质中建立潜伏状态.
- VZV的重新激活会导致疹 (HZ),通常会影响1-2个皮肤段.
- 疹可以导致周围神经并发症,如亨特综合征,疹后神经疼痛和吉兰-巴雷综合征 (GBS).
研究的目的:
- 为了调查罕见的HZ并发症呈现为外围神经病变.
- 探索VZV在HZ相关神经病变中的病理生理学和传播模式,特别是那些在典型皮肤病外的人.
- 提高对各种HZ神经病变的临床认识.
主要方法:
- 对15名患有HZ外围神经病变的日本患者的宿主因素,皮肤病变,神经学和病毒学发现的分析.
- 使用MRI,包括3D NerveVIEW,以评估脊髓和根.
- 与成像结果相关的临床发现,以确定VZV传播模式.
主要成果:
- 确定了6例与HZ皮肤病不同的HZ外围神经病变.
- 描述了罕见的并发症,包括上肢,骨髓激素炎和多根性结核炎.
- 提出了四种潜在的VZV传播途径:上升的脊髓根,上升的脊髓,多根基病变和内传播.
结论:
- HZ外围神经病变可以表现为各种模式,有时与HZ皮肤病无关.
- 已确定的VZV传播途径为这些罕见的神经并发症的病理生理学提供了洞察力.
- 随着年龄的增长,HZ的发病率增加,需要对这些神经病变提高临床警.
关键词:
疹子 疹子 疹子神经病变是一种神经病变.多根核突性尿炎是一种多根核突性尿炎.细分性修行 (segmental paresis) 是指一个细分性修行.脊髓质 (spinal ganglia) 是一个神经系统的组成部分.疹病毒-疹病毒病毒.更多相关视频
09:23Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection
Published on: March 9, 2018
21.6K
12:22A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
17.5K
相关概念视频
01:24Peripheral Nervous System: Ganglia and Nerves
2.0K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
2.0K
01:23Spinal Nerves: Anatomy
3.0K
Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
3.0K
01:20Sympathetic Pathways: Sympathetic Chain Ganglia
2.6K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
2.6K
01:10Spinal Cord: Information Processing
1.3K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
1.3K
01:54The Spinal Cord
29.3K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
29.3K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
839
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
839