由非功能性垂体质量引起的GH缺乏对血清C反应性蛋白水平的影响
Yasufumi Seki1, Satoshi Morimoto1, Kanako Bokuda1
1Department of Internal Medicine, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.
生长激素 (GH) 缺乏与较高的炎症标志物hs-CRP有关. 在下垂体手术后恢复GH分泌可以降低hs-CRP水平,表明GH.
科学领域:
- 内分泌学 在内分泌学.
- 神经内分泌学神经内分泌学
- 炎症研究 炎症研究
背景情况:
- 增长激素 (GH) 缺乏症 (GHD) 与高度敏感性C反应蛋白 (hs-CRP) 的增加有关,这是炎症的标志物.
- 从垂体质量中减少GH分泌与hs-CRP水平之间的确切关系需要进一步阐明.
研究的目的:
- 研究由垂体质量引起的GH分泌受损对hs-CRP水平的影响.
- 为了澄清GH分泌和hs-CRP在下垂体手术前后的关联.
主要方法:
- 追溯分析171名患有非功能性垂体神经内分泌瘤或拉特克裂囊的患者.
- 使用GH释放-2评估GH分泌量,并测量手术前和后血清hs-CRP水平.
- 统计分析包括相关性,多重回归和手术后变化的分析.
主要成果:
- 严重的GHD存在于32%的患者中,并且与显著更高的hs-CRP水平相关 (P < .001).
- 峰值GH水平与hs-CRP负相关 (r = -0.50,P <.001). 它们的高峰值与hs-CRP负相关.
- 较低的峰值GH预测了更高的hs-CRP水平,而术后的峰值GH变化预测了hs-CRP的变化.
结论:
- 由于垂体质量导致的GH分泌受损与hs-CRP水平升高有关.
- GH分泌对增加的hs-CRP起着保护作用,这表明GH与炎症之间存在联系.
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