在国家激素下垂体计划中的自杀 接收者从尸体中获得的人类生长激素
Joseph Y Abrams1, James L Mills2, Lawrence B Schonberger1
1Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Journal of the Endocrine Society
|November 29, 2023
概括
评估了接受尸体来源的人体生长激素 (c-hGH) 治疗的国家激素下垂体计划 (NHPP) 队列中的自杀风险. 虽然整体风险没有显著增加,但特定子组的自杀风险增加,需要进一步研究早期干预.
科学领域:
- 内分泌学和公共卫生
- 自杀风险的流行病学 自杀风险的流行病学
背景情况:
- 报道称,从国家激素下垂体计划 (NHPP) 获得尸体衍生的人类生长激素 (c-hGH) 的接受者自杀,引起了人们的担忧.
- 需要彻底调查c-hGH治疗与增加自杀风险之间的潜在联系.
研究的目的:
- 为了评估NHPP患者队列中的自杀风险.
- 为早期识别和干预策略确定导致自杀风险的特定因素.
主要方法:
- 一项队列研究包括从1957年到2020年接受NHPPc-hGH的患者.
- 使用ICD代码识别了自杀死亡,并计算了标准化死亡率 (SMR).
- 数据与一般人口的自杀率进行了比较,按性别,年龄和时间段分层.
主要成果:
- 在6272名患者中,记录了55例自杀死亡 (SMR=1.25).
- 在男性 (SMR=1.33),25-34岁的个人 (SMR=1.79),以及1985-1998年期间 (SMR=1.70) 观察到自杀风险增加.
- 仅用ICD代码确定了47起自杀事件,而预期的数量为37.8.8.
结论:
- 在NHPPc-hGH接受者中,整体自杀率并不显著高于一般人群.
- 特定的子组,包括男性和年轻人,可能面临自杀风险较高.
- 进一步的研究对于了解和减轻c-hGH接受者的自杀风险至关重要.
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