总摄入量与患有1型糖尿病的青少年女孩的脊椎骨密度有关
Rylee K Saunders1, Kathleen M Kilroe1, Taïsha V Joseph1
1Endocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.
JBMR plus
|November 29, 2023
概括
1型糖尿病 (T1D) 会增加骨折的风险. 这项研究发现,摄入量对T1D年轻人的骨矿物质密度和强度产生积极影响,这表明饮食中的对这一群体的骨健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性骨疾病 代谢性骨疾病
- 儿科内分泌学 儿科内分泌学
背景情况:
- 1型糖尿病 (T1D) 与骨折风险增加,骨矿物质密度 (BMD) 降低和骨微型架构受损有关.
- 足够的 (Ca) 摄入量对于骨矿化和增强骨质量至关重要.
研究的目的:
- 调查T1D和没有T1D的青少年女孩每日总摄入量与骨健康结果之间的关联.
主要方法:
- 对10至16岁的女孩进行横截面分析,其中62名被诊断为T1D,60名为对照组.
- 摄入量通过食品频率调查问卷进行评估.
- 使用双能X射线吸收度和高分辨率外围定量计算断层扫描评估的BMD,微架构和强度.
主要成果:
- 在T1D和对照组之间,每日摄入量没有显著差异.
- 患有T1D的青少年表现出较低的血清25-基维生素D和较高的副甲状腺激素水平.
- 在T1D组中,在骨观察到下椎体积BMD和厚度.
- 在T1D参与者中,摄入量与半径和骨的椎骨质量相关,并且与骨的估计失效负荷相关,但不是对照组.
- 在对照组中存在Ca摄入量和副甲状腺激素之间的反向关系,但在T1D参与者中没有.
结论:
- 患有T1D的青少年可能更容易受到饮食中不足的负面影响.
- 增加摄入量可能是改善T1D年轻人骨健康的有益策略.
相关概念视频
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Skeleton and Calcium Homeostasis
4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K
Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Synthesis and Functions of Calcitonin
1.9K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.9K
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K


