史无前例的合成一个14个成员的六合相宏循环
Anastasia A Fesenko1, Anatoly D Shutalev1
1N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., 119991 Moscow, Russian Federation.
Beilstein journal of organic chemistry
|November 29, 2023
概括
研究人员详细介绍了一种新型的14个成员的宏循环的合成,2,10-二甲基-2,8,10,16-四二烯醇[3,4-e:3].
科学领域:
- 有机化学 有机化学
- 超分子化学 超分子化学
- 异环化学 异环化学
背景情况:
- 皮拉衍生物是有机合成中的多功能构建块.
- 宏环化合物具有独特的结构和功能特性.
- 复杂的异环宏循环的合成仍然是一个挑战.
研究的目的:
- 为了研究一个pyrazole前体的详细转化到一个特定的14个成员的宏观循环.
- 阐明反应机制,包括中间体的形成和二元化.
- 开发一个方便的合成路径到目标宏循环.
主要方法:
- 在各种条件下,3-[(乙氧甲) 氨基]-1-甲基-1H-pyrazole-4-carbonitrile与多余的水的反应.
- 隔离和介质4-imino-2-methyl-2,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine的特征.
- 介质的二元化形成最终的宏观循环.
- 用于结构阐明的光谱和分析技术.
主要成果:
- 这种反应成功地产生了14个成员的宏循环,2,10-二甲基-2,8,10,16-四基二razol[3,4-e:3',4'-l][1,2,4,8,9,11]hexaazacyclotetradecine-4,12-diamine.
- 反应途径涉及到一个pyrazolopyrimidine中间体的形成和随后的二元化.
- 建立了一个从中间体开始的宏观循环的实用合成.
- 为宏观循环提出了一个可信的自我组装途径.
结论:
- 该研究提供了对宏循环形成机制的详细了解.
- 为目标宏观周期开发了一种方便和高效的合成方法.
- 这些发现有助于宏环化学和异环合成领域.
- 对宏观循环的结构和反应性质进行进一步的研究是有必要的.
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