在被送往重症监护室的婴儿中使用黑色素
Caitlyn Bradford1, Jamie L Miller2, Maura Harkin3
1Department of Pharmacy Practice (CB), Philadelphia College of Pharmacy, Saint Joseph's University, Philadelphia, PA.
概括
这项研究发现,黑激素对重症监护中的婴儿是安全的,主要用于促进睡眠. 虽然它减少了阿片类药物的使用,但它没有改善这个婴儿群体的疼痛或镇静得分.
科学领域:
- 儿科重症监护室的儿童重症监护室
- 新生儿药理学 新生儿药理学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠不足是重症监护室 (ICU) Delirium 的重要危险因素.
- 黑素用于预防和治疗妄想症,但对其在婴儿中的安全性和有效性的数据有限.
- 了解黑激素在婴儿护理中的作用对于优化治疗策略至关重要.
研究的目的:
- 调查婴儿进入ICU时使用黑色素的指示,剂量,疗效和安全性.
- 为了解决有关在这个脆弱的患者群体中服用黑色素的知识差距.
主要方法:
- 一项描述性,回顾性研究,涉及12个月以下的婴儿,他们在ICU中接受黑色素.
- 收集的数据包括患者人口统计,黑激素疗法,并发镇静剂,止痛剂和抗精神病药物.
- 统计分析,包括威尔科克森签名等级测试和线性混合模型,用于评估结果.
主要成果:
- 纳入了55名婴儿,其中黑激素的主要指示是促进睡眠 (52.7%).
- 基于体重的中位数剂量为0.31 mg/kg/剂量.
- 在黑激素开始后观察到累积阿片类药物剂量的统计显著减少 (p = 0.049),尽管疼痛和镇静得分没有改善.
结论:
- 黑色素通常用于促进婴儿在ICU环境中的睡眠,其中位数剂量为0.31 mg/kg/剂量.
- 启动黑激素与婴儿阿片类药物暴露的减少有关.
- 需要进一步的研究,因为黑激素在本研究队列中没有显示出对疼痛或镇静得分的显著影响.
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