高证据,可操作的表型基因分布在多专业,三级护理诊所:潜在可操作的基因和参考部门概况
Blake Bartlett1, Sheena Crosby2, Michael J Schuh3
1University of Florida College of Pharmacy.
Innovations in pharmacy
|November 29, 2023
概括
药物基因组测试显示,几乎所有患者都有高证据可操作的表型 (HEAP),这可能会影响药物安全性. 通过药理基因组学 (PGx) 识别这些遗传变异对于个性化医疗和减少患者伤害至关重要.
科学领域:
- 药物基因组学 药物基因组学
- 临床药房 临床药房
- 遗传学 是一个遗传学.
背景情况:
- 个性化医疗是一种日益增长的趋势,药物基因组学 (PGx) 根据患者遗传学指导药物选择.
- 一家三级医疗保健诊所使用PGx结果进行专家的综合药物审查.
- 该实践将PGx集成到临床工作流程和电子医疗记录中.
研究的目的:
- 为了描述药物基因组测试的患者.
- 在这个人群中确定高证据可操作表型 (HEAP) 基因的流行率.
- 为PGx服务提供有针对性的营销和部门宣传信息.
主要方法:
- 来自27个基因的药物基因组组的遗传数据的分析.
- 将遗传变异分类为HEAP和低证据非可操作的表型 (LENP).
- 评估来自第三级护理诊所的参考人群的患者数据.
主要成果:
- 在154名患者中发现了1236种非典型的表型.
- 39.97%的非典型基因被归类为HEAP,而60.03%是LENP.
- 98.7%的患者拥有至少一个HEAP基因,主要涉及CYP2D6,VKORC1和UGT1A1.1.
结论:
- 在转诊患者中存在HEAP基因的高患病率,这表明存在与药物相关的安全问题.
- 药物基因组咨询可以减轻与HEAP基因相关的风险,可能降低发病率,死亡率和医疗保健成本.
- 常规的PGx测试和将其纳入临床实践对于推进个性化医学的发展至关重要.
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