对儿童和成年人的结构形态测量进行比较,这些儿童和成年人患有持续发育性口吃
Hilary E Miller1, Emily O Garnett2, Elizabeth S Heller Murray1,3
1Department of Speech, Language, & Hearing Sciences, Boston University, Boston, MA 02215, USA.
Brain communications
|November 29, 2023
概括
吃的孩子在语音区域的皮质较薄,与严重程度有关. 吃的成年人表现出不同的大脑模式,这表明网络随着时间的推移而变化. 这项研究探讨了口吃发育中的神经解剖学.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 语音和语言科学 语言科学
背景情况:
- 吃是一种复杂的语言障碍,其神经解剖学基础不清楚.
- 以前的研究已经产生了不一致的发现,关于的人的大脑差异.
- 区分早期神经解剖学变异与与长期口吃相关的变异至关重要.
研究的目的:
- 为了研究与对照人群相比,口吃的儿童和成年人的神经解剖学差异.
- 为了确定观察到的差异是否反映了核心赤字或由于口吃的持续时间而发生的变化.
- 探索结构形态与口吃严重程度之间的相关性.
主要方法:
- 从T1加权MRI扫描中分析结构形态的横截面研究.
- 使用FreeSurfer软件提取皮质大小 (表面积,厚度) 和旋转,以及皮质下体积.
- 采用ANOVA进行统计分析,以错误发现率纠正,并测试了与口吃严重程度的相关性.
主要成果:
- 吃的孩子表现出语言规划区域的皮质较薄,与吃的严重程度相关.
- 吃的成年人没有表现出这些皮质厚度差异,但在右下额头回环中显示出减少的转.
- 研究结果表明,早期口吃与成年后持续口吃之间存在着不同的神经解剖学特征.
结论:
- 语音规划区域的早期皮质异常可能会导致口吃的开始.
- 成年后持续的口吃可能涉及网络层面的功能障碍,而不是焦点形态差异.
- 由于生活经验,口吃的成年人可能会呈现出更异质的神经特征.
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