应激反应期婴儿与子宫内生长限制和成人疾病理论之间的相关性
Manal Eldegeir1, Cornelius Ani2, Sally McGregor3
1JACO NGO
Qatar medical journal
|November 29, 2023
概括
患有子宫内增长迟缓的婴儿表现出的生理和行为应激反应. 这种与严重程度相关的抑制可能会让他们更容易患上未来的健康问题,如过敏和自身免疫性疾病.
科学领域:
- 新生儿生理学和应激反应.
- 健康和疾病的发育起源.
背景情况:
- 每年有数以百万计的婴儿出生时体重低 (LBW) 或子宫内生长限制 (IUGR),特别是在苏丹等发展中国家.
- 母亲营养不良和粮食不安全加剧了LBW和IUGR的发生率,影响了婴儿的健康.
- IUGR与发育障碍有关,可能是通过下丘脑-垂体-上腺 (HPA) 轴的子宫内编程.
研究的目的:
- 为了研究生理和行为应激反应在期生LBW (T-LBW) 婴儿与期生正常出生体重 (T-NBW) 婴儿相比.
- 评估T-LBW与T-NBW新生儿的休息状态和体力压力因素后的唾液皮质醇水平.
- 为了比较T-LBW和T-NBW新生儿对身体压力的行为反应.
主要方法:
- 一项基于医院的匹配病例控制研究,涉及65名T-LBW新生儿 (病例) 和67名T-NBW新生儿 (对照).
- 参与者根据年龄 (4-6小时),妊娠年龄和分娩方式进行了匹配.
- 测量包括人体测量,唾液皮质醇 (前和后刺) 和行为评级.
主要成果:
- 与对照组相比,IUGR新生儿的体积显著更小,基底皮质醇水平较低.
- 在经历了压力因素后,IUGR新生儿的皮质醇反应减弱,哭泣力也减弱.
- 人类测量指标与行为和皮质醇反应有积极的相关性;衰老更与行为抑制有关,而不是消耗.
结论:
- 子宫内生长迟缓的严重程度与新生儿抑制的行为和生理应激反应有关.
- 这种生理抑制可能会导致晚年"不匹配疾病"的发展.
- 研究结果强调了IUGR对健康的长期影响以及早期营养的重要性.
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