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在女性患者的甲状腺功能水平的变化,第一次发作双相情感障碍
Xiuhua Song1, Yufang Feng1, Lei Yi1
1Department of Psychiatry, Mental Health Center of Qingdao City, Qingdao, Shandong Province, China.
Frontiers in psychiatry
|November 29, 2023
概括
甲状腺激素水平与双相情感障碍的发生有关. 在患有抑郁症或躁狂症的患者中观察到较低的甲状腺激素水平 (T3,T4),这表明甲状腺功能障碍是他们的第一个发作.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 生物标志物发现发现
背景情况:
- 双极性障碍的诊断和治疗可以通过识别分子生物标志物来改进.
- 甲状腺激素在神经和精神功能中起着至关重要的作用.
研究的目的:
- 研究血液甲状腺激素水平与双相情感障碍患者的第一发作类型之间的关联.
- 探索甲状腺激素水平作为不同双相情感障碍表现的潜在生物标志物.
主要方法:
- 一项病例对照研究,涉及120名女性双相情感障碍患者 (60名抑郁症首发,60名躁狂/催眠症首发) 和60名健康对照.
- 测量血清三甲状腺素 (T3),甲状腺素 (T4),自由三甲状腺素 (FT3),自由甲状腺素 (FT4) 和甲状腺刺激激素 (TSH).
主要成果:
- 患有躁狂/低躁狂的患者首次发病的情节持续时间比患有抑郁症首次发病的患者要短.
- 甲状腺异常的患病率在抑郁症第一次发作组 (60%) 发现较高,而在躁狂/催眠症第一次发作组 (27%) 发现较高.
- 与对照组相比,双极性障碍组的T3和T4水平明显较低,躁狂/低躁狂组的T3和FT3水平高于抑郁组.
结论:
- 甲状腺功能障碍,通过血中甲状腺激素水平的降低表明,可能导致双相情感障碍的进展.
- 血中的甲状腺激素水平与双相情感障碍患者的临床症状相关,患者在第一次发作时经历了抑郁症或躁狂症.
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