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心率变化指标表明,在老鼠的焦虑类行为期间,自主调节的性别差异
Raizel M Frasier1,2, Thatiane De Oliveira Sergio1, Phillip A Starski1
1Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States.
Frontiers in psychiatry
|November 29, 2023
概括
这项研究揭示了自主神经系统在引发焦虑的情况中的反应的性别差异. 雌性老鼠表现出更高的心率和较低的同情活动,影响它们的行为和食物摄入量不同于雄性.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 行为科学 行为科学
背景情况:
- 心理健康状况,特别是焦虑症,在女性中更为普遍.
- 了解潜在的生物机制,特别是自主神经系统 (ANS) 调节中的性别差异,至关重要.
- 心率 (HR) 和心率变化 (HRV) 作为ANS平衡 (交感和副交感系统) 和潜在生物标志物的指标.
研究的目的:
- 用老鼠模型研究与焦虑相关的自主机制中的性别差异.
- 为了将心率和心率变化指标与在新性诱导的食抑制任务期间的行为反应相关联.
主要方法:
- 成年限制食物的老鼠 (雄性和雌性) 进行了远程测量,以监测HR/HRV.
- 在新性抑制养 (NSF) 任务中评估了行为.
- 用SDNN (交感和副交感影响) 和rMSSD (副交感影响) 分析HRV.
主要成果:
- 与男性相比,女性表现出更高的基线HR和较低的交感神经系统 (SNS) 指标.
- 基底HR较高的女性在NSF期间延迟接近中心.
- 较低SNS指标的男性更多地参与了中央竞技场,而更高的SNS与男性的食物消费增加相关.
结论:
- 这些发现与人类数据一致,表明女性更多地依赖于副交感神经系统 (PNS),而男性则依赖于SNS.
- 确定了ANS活动 (HRV) 和行为之间的性别特异关系,这对焦虑和养行为有影响.
- 这些结果突出了心脏自主功能和行为之间的相互作用中的新,临床相关的性别差异.
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