失调的诺拉丁反应与精神分裂症患者的症状严重程度有关
Ana Pelegrino1,2, Anna Luiza Guimaraes1,2, Walter Sena1,2
1Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Frontiers in psychiatry
|November 29, 2023
概括
精神分裂症患者的瞳孔扩张有所减少,这表明局部coeruleus-noradrenaline (LC-NA) 活动发生变化,特别是在任务需求增加的情况下. 这种诺亚上腺反应与症状严重程度有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 位置 - 诺亚上腺素 (LC-NA) 系统影响认知功能.
- 在LC-NA系统的变化与精神分裂症有关.
- 任务唤起的瞳孔反应提供了LC活动的非侵入性测量.
研究的目的:
- 调查精神分裂症症状学,认知功能和诺亚氨酸反应之间的关联.
- 检查精神分裂症患者和健康对照者之间的任务唤起的瞳孔反应差异.
- 探索学生反应和精神分裂症症状严重程度之间的关系.
主要方法:
- 评估了在支持和反动任务期间的任务引起的瞳孔扩张.
- 包括23名精神分裂症患者和28名健康患者.
- 利用瞳孔测量来测量认知任务期间的瞳孔膨胀.
主要成果:
- 与健康受试者相比,精神分裂症患者在抗分试验中表现出明显较低的瞳孔扩张.
- 在精神分裂症患者中,针对抗克试验的准备性瞳孔扩张减少了.
- 减少的瞳孔扩张在抗相卡德试验与增加的精神分裂症的一般症状相关.
结论:
- 任务唤起的瞳孔反应,反映LC-NA活动,在精神分裂症中发生变化,特别是在认知需求增加时.
- 减少的诺亚上腺反应与精神分裂症的症状严重程度更大有关.
- 调节诺亚上腺素路径可能为精神分裂症提供治疗潜力.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
49
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
49
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
681
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
681
Biological Causes of Schizophrenia
60
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
60
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
121
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
121
Psychological and Sociocultural Causes of Schizophrenia
91
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
91
Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68


