在接受手术的创伤患者中,血清甲胺阳性对术后发病率和死亡率没有负面影响
James Zhou1,2,3, Adela Wu2, Jingya Miao4
1Department of Clinical Medicine, California Northstate University College of Medicine, Elk Grove, USA.
Journal of emergencies, trauma, and shock
|November 29, 2023
概括
在创伤手术患者中使用甲基胺并没有增加死亡率或并发症. 伤害严重程度得分 (ISS) 是一个比METH状态更强的预测结果.
科学领域:
- 创伤外科 手术 创伤外科
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 甲基胺 (METH) 对手术结果的影响,特别是对创伤患者的影响,尚不清楚.
- 与METH使用相关的术后并发症和死亡风险需要进一步调查.
研究的目的:
- 为了比较甲基胺阴性 (METH-) 和甲基胺阳性 (METH+) 创伤患者之间的手术结果.
- 确定METH使用是否是创伤外科手术中死亡率或发病率的预测因素.
主要方法:
- 对571名接受手术的创伤患者 (2015-2020年) 的回顾性图表审查.
- 患者分为METH- (n=421) 和METH+ (n=150) 组.
- 单变量和多变量分析比较了包括伤害严重性得分 (ISS),并发症和死亡率在内的结果.
主要成果:
- 在METH+患者中,ISS的中位数较低 (P=0.0478).
- 在单变量分析中,METH和METH+组之间死亡率或发病率没有显著差异.
- 多变量分析显示,METH不是死亡率或发病率的预测因素;ISS预测了两者 (死亡率P=0.048,发病率P<0.001).
结论:
- 在急性创伤手术中,甲基胺使用似乎不会增加死亡率或发病率.
- 伤害严重性评分 (ISS) 是创伤手术患者的结果的一个更重要的预测指标.
- 伤害严重程度和病因是评估创伤手术结果的关键因素.
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