不变的自然杀伤性T细胞和首次冠状动脉事件的发生率:一个嵌套病例控制研究
Lukas Tomas1, Pernilla Katra1, Wiaam Badn1
1Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
European heart journal open
|November 29, 2023
概括
高水平的双阴性 (DN) 恒定性自然杀手T (iNKT) 细胞与人类冠状动脉事件的风险降低有关. 这一发现与小鼠研究相反,表明DN iNKT细胞在心血管疾病中起着保护作用.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管疾病研究研究
- 脂质代谢 脂质代谢是什么
背景情况:
- 不变的自然杀手T (iNKT) 细胞是脂质抗原识别免疫细胞.
- 以前的小鼠研究表明,iNKT细胞促进动脉样硬化.
- 缺乏对iNKT细胞和冠状动脉事件的人类研究.
研究的目的:
- 为了研究循环iNKT细胞和人类的冠状动脉事件 (CE) 之间的关联.
- 确定iNKT细胞子集是否与CE有差异性关联.
- 为了澄清iNKT细胞在失脂血症驱动的心血管疾病中的作用.
主要方法:
- 流式细胞计量用于在人类队列中的iNKT细胞 (n=416).
- 使用了一个嵌入在马尔默饮食和癌症研究中的病例对照研究.
- 对于事件CE的中位数为14年,进行了随访.
主要成果:
- 较高的CD4-CD8-双阴性 (DN) iNKT细胞水平与发生的CE显著反向相关 (OR 0.62,P=0.046).
- 在调整心血管风险因素 (OR 0.57,P=0.046) 之后,这种关联仍然显著.
- 总的iNKT细胞和其他子集与事件CE没有显著的关联.
结论:
- 结果表明,在循环DN iNKT细胞较高的情况下,发生CE的风险降低.
- 动物研究表明的亲动脉产生作用可能不适用于人类心血管疾病.
- 高数量的DN iNKT细胞可能对人类的心血管事件有保护作用.
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