调查改变的大脑功能枢纽和冠状动脉疾病与认知障碍的因果联系
Rui Qin1, Tong Li1, Cuicui Li1
1Department of Radiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong Province, China.
PeerJ
|November 29, 2023
概括
冠状动脉疾病 (CAD) 患者的脑连接性降低,特别是在左侧准海马皮质和中侧回,影响认知功能. 这些大脑网络的变化可能解释了CAD的认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 心血管研究研究心血管研究
背景情况:
- 冠状动脉疾病 (CAD) 和认知障碍 (CI) 构成了全球重大健康挑战.
- 虽然在CAD患者中记录了区域性大脑功能变化,但大脑网络连接的改变仍未得到充分研究.
- 了解这些网络变化对于解释CAD认知衰退至关重要.
研究的目的:
- 为了研究CAD患者的休息状态大脑网络连接.
- 通过度中心性 (DC) 和光谱动态因果建模 (spDCM) 来分析有效的连接强度和方向性.
- 为了识别功能中心和异常连接,导致大脑功能变化和CAD的认知衰退.
主要方法:
- 与24名CAD患者和24名匹配的健康对照 (HC) 进行前性研究.
- 功能性MRI (fMRI) 用于评估大脑活动;神经心理测试用于认知功能.
- 度中心性 (DC) 分析和光谱动态因果建模 (spDCM) 用于研究大脑网络.
主要成果:
- 患有CAD的患者的认知功能明显低于HC患者.
- 在CAD患者的左侧副海马皮层 (PHC) 和左侧中间回 (MTG) 中观察到降低的DC值.
- 观察到有效连接的变化,包括右上额头 (SFG) 和PHC之间没有正连接,PHC/MTG与SFG之间的负连接增加,PHC和MTG之间的正连接减少.
结论:
- 涉及SFG,PHC和MTG的大脑网络连接的改变可能会调解CAD患者的认知功能变化.
- 神经成像证据表明,特定的网络中断有助于CAD的认知衰退.
- 研究结果强调了心血管健康和影响认知的大脑网络完整性之间的联系.
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