在膀癌中涉及的遗传多态性:全球综述
Hampig Raphael Kourie1, Joseph Zouein1, Bahaa Succar1
1Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Oncology reviews
|November 29, 2023
概括
遗传变异,特别是单核酸多态 (SNP),影响膀癌 (BC) 的风险. 这项研究确定了关键的基因和SNP与BC易感性相关,不包括环境因素.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 膀癌 (BC) 具有遗传易感性.
- 已知单核酸多态 (SNP) 影响BC风险.
- 以前的研究已经确定了与BC的众多遗传关联.
研究的目的:
- 系统地审查和识别与膀癌相关的基因和SNP.
- 专注于独立于吸烟和环境暴露的遗传因素.
- 根据功能对已识别的遗传变异进行分类.
主要方法:
- 从2000年1月到2020年10月进行了全面的文献搜索.
- 最初选择了334篇文章,报告了244个基因中的455个SNP.
- 与吸烟和环境因素相关的SNP被排除在外,随后对一致结果进行了分析.
主要成果:
- 总共有197个基因和343个SNP被发现与BC相关.
- 177个基因和291个SNP在研究中显示出一致的结果.
- 这些验证的基因和SNP在功能上被分为八个组.
结论:
- 特定的基因和SNP始终与膀癌的遗传易感性有关.
- 这份精心策划的遗传因素清单为进一步的BC研究提供了基础.
- 了解这些遗传基础可以帮助识别有风险的个体.
相关概念视频
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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