便中乳酸的轨迹用于预测性结肠炎的预后
Rirong Chen1, Li Li1, Yizhe Tie1
1Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Precision clinical medicine
|November 29, 2023
概括
便中的乳托费林轨迹预测了用ustekinumab治疗的性结肠炎 (UC) 患者的缓解. 这种生物标志物为在一年内实现内镜,临床和组织学缓解提供了宝贵的预后见解.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 生物标志物发现发现
背景情况:
- 性结肠炎 (UC) 管理需要可靠的预后标志物.
- 便中的乳酸是肠道炎症的新兴生物标志物.
研究的目的:
- 在UC患者中描述便中乳酸的轨迹.
- 评估这些轨迹对治疗结果的预后价值.
主要方法:
- 隐性类增长混合建模用于分析UNIFI试验中的便中乳酸,便中calprotectin和CRP水平.
- 数据包括637名患者用于诱导建模和403名患者用于1年后果分析.
主要成果:
- 确定了便中乳酸,calprotectin和CRP的不同轨迹,这些轨迹受先前的生物暴露的影响.
- 便中乳酸的轨迹是1年内内镜,临床和组织学缓解的最强预测因素.
- 一个基于便中的乳托费林的患者分层方案显示了1年内镜缓解的明显概率 (52.7%好,30.9%中度,12.8%差).
结论:
- 便中乳酸的轨迹是UC的有价值的预后指标.
- 这种分析为预测缓解提供了一个新的患者分层工具.
- 这些发现支持用于个性化UC管理的便乳酸的使用.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
Ultrasound II: Endoscopic Ultrasound and FibroScan
113
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
113
Serum Laboratory Studies, Stool Test, Breath Test
351
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
351


