脑下垂体神经元输出在发动机启动开始时传递传感运动信号
Ekaterina Martianova1, Renata Sadretdinova1, Alicia Pageau1
1CERVO Brain Research Center, Department of Psychiatry and Neurosciences, Université Laval, Québec, QC, Canada.
iScience
|November 29, 2023
概括
侧向下丘脑 (LH) 通过传输感觉运动信号来协调行为. 三个LH神经输出到背面的拉菲核,腹膜区域和侧面的 habenula 显示出运动前的连贯活动.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 系统神经科学 系统神经科学
背景情况:
- 侧向下丘脑 (LH) 对于整合感官信息来组织行为反应至关重要.
- 预测定义的LH神经输出通过何种精确的机制来动态地将传感器信号传输到下游的目标,仍然在很大程度上是未知的.
研究的目的:
- 为了调查特定的LH神经输出如何在行为过程中将传感器信号传输到主要下游目标.
- 阐明不同的LH投射途径在组织运动反应中的作用.
主要方法:
- 采用多纤维光度测量来记录LH轴突终端的神经元活动.
- 使用光遗传刺激来激活特定的LH投射通路.
- 在小鼠中进行了包括运动启动,被动回避和糖消费在内的行为测试.
主要成果:
- 三个主要的LH神经输出线向背面的拉菲核 (DRN),腹膜区域 (VTA) 和侧面的 habenula (LHb) 投射,在感官唤起和自我启动的运动反应期间表现出一致的活性.
- 轴突终端的LH活性增加在主动应对行为的运动启动之前.
- 在DRN,VTA或LHb中LH轴突终端的光遗传激活促进了运动启动,对被动回避和奖励行为产生了差异性影响.
结论:
- 这项研究揭示了在运动控制过程中三个关键的LH投射途径之间的协调活动模式.
- 这些投影定义的LH输出在运动开始时在向下游区域传输传感器信号方面发挥着互补的作用.
- 这些发现提供了从侧向下丘脑起源的基本行为组织的神经电路的见解.
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