在接受抗逆转录病毒治疗的艾滋病毒感染者中,体重变化的纵向轨迹:一项基于小组的研究
Xinsheng Wu1, Lukun Zhang2, Zhen Lu1
1School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
iScience
|November 29, 2023
概括
在某些抗逆转录病毒疗法 (ART) 方案 (包括dolutegravir,raltegravir和lopinavir) 上,艾滋病毒感染者 (PLHIV) 显示出更高的快速体重增加率. 建议加强对这些患者的营养监测.
科学领域:
- 传染性疾病 传染性疾病
- 艾滋病毒/艾滋病研究研究
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染者 (PLHIV) 体重变化在各种抗逆转录病毒疗法 (ART) 方案中有所不同.
- 了解这些体重轨迹对于管理PLHIV的长期健康结果至关重要.
研究的目的:
- 为了确定在PLHIV发起ART的不同纵向重量变化轨迹.
- 为了确定与这个人群的快速体重增加相关的因素.
主要方法:
- 利用生长混合模型 (GMM) 对12683例PLHIV.体重变化的多轨迹分析.
- 采用多重后勤回归来确定快速体重增加的相关性.
- 从2003年1月至2022年9月期间在中国深的一家医院接受ART治疗的患者收集的数据.
主要成果:
- 确定了两个主要的体重变化轨迹:缓慢增加 (70.5%) 和快速增加 (29.5%).
- 与基于dolutegravir, raltegravir或lopinavir的疗法启动ART的PLHIV显示,与基于efavirenz的疗法相比,快速体重增加的几率明显更高.
- 快速增加体重的具体调整的几率比 (aOR) 是:杜洛特格拉维尔 (2.46),拉尔特格拉维尔 (2.74) 和洛皮纳维尔 (1.62).
结论:
- 某些ART疗法 (多卢特格拉维尔,拉尔特格拉维尔,洛皮纳维尔) 与PLHIV患者快速体重增加的可能性增加有关.
- 定期监测营养状况对于PLHIV启动这些特定的ART疗程至关重要.
- 进一步的研究可能会探索与ART相关的体重变化背后的机制,并优化患者管理.
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