预测系统炎症反应指数对非透析患者慢性病进展的预测效应
Leile Tang1, Ying Deng2, Jiahui Lai2
1Department of Cardiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Journal of inflammation research
|November 29, 2023
概括
系统性炎症反应指数 (SIRI) 与非透析患者的慢性病 (CKD) 进展有关. 较高的SIRI水平独立地预测功能恶化,突出显示其作为CKD预后标志物的潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 炎症标志物的炎症标志物
- 生物统计学 生物统计学
背景情况:
- 慢性病 (CKD) 影响全球数百万人,对其进展的预测标志物的理解有限.
- 系统性炎症反应指数 (SIRI) 是一个反映系统性炎症的新兴生物标志物.
- 关于SIRI和CKD进展之间的关联的研究很少,特别是在非透析患者中.
研究的目的:
- 在患有慢性病的成年患者中调查SIRI与功能之间的关联.
- 评估SIRI在预测非透析患者中CKD进展的疗效.
主要方法:
- 分析了1420名成年非透析CKD患者的队列.
- 使用后勤回归和Cox比例危险模型来评估SIRI的关联性和预测价值.
- 进行了子组分析,以探索与人口和临床因素的相互作用.
主要成果:
- 增加的SIRI水平与年龄较大,男性性别以及高血压和心力衰竭等并发症有关.
- 观察到基线水平较高的肌素和C-反应蛋白,以及降低的EGFR和血红蛋白,以及较高的SIRI.
- ln(SIRI) 独立地与晚期CKD (OR=1.59) 相关,并预测CKD进展 (HR=1.3),在性别,年龄和高血压方面发现了显著的相互作用.
结论:
- SIRI与功能有显著的关联,并且可以独立预测预先透析患者的CKD进展.
- 在监测CKD进展方面,SIRI显示出作为一种有价值的预后生物标志物的潜力.
- 需要进一步的研究来阐明SIRI在CKD管理中的潜在机制和临床实用性.
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