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适应性免疫系统的干扰伴随着在COVID-19疫苗接种后在SARS-CoV-2感染期间住院的患者血短链脂肪酸的减少

Zhaojun Liang^1,2, Nan Wang^1,2, Chunxue Fan^1,2

¹Division of Rheumatology, Department of Medicine, the Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.

Journal of inflammation research

|November 29, 2023

概括

即使接种了疫苗的COVID-19患者,也显示出免疫细胞减少和较低的短链脂肪酸 (SCFA). 这些SCFA水平可能与淋巴缺血有关,为2019年新冠肺炎疾病提供了新的治疗点.

科学领域:

免疫学免疫学免疫学
微生物组研究微生物组研究
传染性疾病传染性疾病

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染影响免疫功能和肠道微生物群多样性.
了解COVID-19中免疫细胞和肠道代谢物之间的相互作用至关重要.

研究的目的:

为了研究COVID-19患者循环免疫细胞子集的变化.
在COVID-19患者中分析短链脂肪酸 (SCFA) 的血水平.
探索免疫细胞和SCFA在COVID-19病变发生过程中的关系.

主要方法:

包括83名COVID-19患者和39名控制组,所有人都接种了疫苗.
流细胞计测对外围淋巴细胞子集和血细胞因子.
用于血SCFA量化目标代谢量.

主要成果:

与对照人群相比,COVID-19患者的CD19+B细胞,CD4+T细胞,CD8+T细胞和NK细胞减少.
在COVID-19患者中观察到sIL-2R,IL-6和IL-10水平升高.
在COVID-19患者中发现血中酸,黄油酸,异黄油酸和异酸水平降低.

结论:

接种了COVID-19疫苗的患者仍然存在显著的免疫细胞干扰和较低的SCFA,特别是危急病例.
血SCFA的减少可能导致COVID-19中的淋巴衰竭.
SCFA和免疫细胞减少之间的相关性表明COVID-19的新型治疗策略.

关键词:

适应性免疫是一种适应性免疫.新冠病毒疾病2019年严重急性呼吸系统综合征新冠病毒2 短链脂肪酸短链脂肪酸

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