相关实验视频
Updated: Jul 9, 2025
06:39
Real-Time Void Spot Assay
Published on: February 10, 2023
2.0K
美国成年人接触有机酸和膀过活之间的关联:一个横截面研究
Weilong Lin1, Haoxu Wang1, Zesong Wu2
1The First Affiliated Hospital of Shantou University Medical College, Medical College of Shantou University, Shantou, Guangdong, China.
Frontiers in public health
|November 29, 2023
概括
暴露于二酸 (DPHP),一种有机酸代谢物,与美国成年女性过度活性膀 (OAB) 的风险增加有关. 需要进一步的研究来了解这种关联背后的机制.
科学领域:
- 环境健康 环境健康
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 毒理学 毒理学 毒理学
背景情况:
- 有机酸 (OPEs) 暴露与过度活性膀 (OAB) 风险之间的联系尚不清楚.
- OPE在工业和消费品中广泛使用,导致人类潜在暴露.
- 尿中代谢物作为OPE暴露的生物标志物.
研究的目的:
- 调查尿中OPE代谢物与OAB的流行率之间的关联.
- 为了确定可能与OAB风险相关的特定OPE代谢物.
主要方法:
- 利用了2011-2016年国家健康和营养检查调查 (NHANES) 的数据.
- 分析了四种尿中的OPE代谢物:二烯酸 (DPHP),二 (1,3-二二) (BDCPP),二 (2-乙烯) (BCEP) 和二烯酸 (DBUP).
- 采用多变量逻辑回归和受限立方线 (RCS) 分析,并进行子组和相互作用分析.
主要成果:
- 总共包括了3,443名美国成年人;597人患有OAB.
- 在整体队列中,DPHP度的增加与OAB风险有关.
- 这种关联在女性中是显著的,通过RCS分析观察到非线性剂量反应关系.
结论:
- 暴露于二酸 (DPHP) 可能会增加美国成年女性过活性膀 (OAB) 的风险.
- 这些发现突出了OAB的潜在环境风险因素.
- 需要进一步的实验研究来阐明潜在的机制.
相关概念视频
01:26Anticholinesterase Agents: Poisoning and Treatment
877
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
877
01:20Disorders of the Urinary System
322
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
322
01:36Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
684
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
684
01:26The Micturition Reflex
668
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
668
01:31Direct-Acting Cholinergic Agonists: Pharmacokinetics
1.2K
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
1.2K