功能化二氧化纳米颗粒与抗氧化神经保护对阿尔茨海默氏症的疾病
Yu Hu1,2,3, Hui Guo1,2,3, Shuai Cheng1,2,3
1School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, People's Republic of China.
International journal of nanomedicine
|November 29, 2023
概括
这项研究开发了载有复星 (LMC-RES) 的二氧化纳米颗粒,用于对抗阿尔茨海默病. 在AD小鼠中,LMC-RES有效地穿越血脑屏障,减少氧化应激,并改善认知功能.
科学领域:
- 纳米技术 纳米技术
- 神经科学是一个神经科学.
- 生物化学 生化学
背景情况:
- 阿尔茨海默病 (AD) 与氧化压力和粉样β (Aβ) 聚合有关.
- 二氧化和氧化纳米颗粒是神经保护的有效ROS清理器.
研究的目的:
- 为了合成和表征含有的二氧化纳米颗粒,加载了Resveratrol (LMC-RES).
- 评估LMC-RES在阿尔茨海默氏病模型中的生物相容性,血脑屏障 (BBB) 透率和治疗疗效.
主要方法:
- 含的空心结构二氧化纳米颗粒 (LMC) 合成并装有复星 (RES).
- 使用TEM,DLS,Zeta潜力和X射线能量谱分析进行表征.
- 在体外抗氧化剂测定,在AD小鼠体内生物分布研究,认知测试 (水迷宫,筑巢) 和组织学分析.
主要成果:
- LMC-RES显示持续释放 (80.9%在24小时内) 和良好的生物相容性.
- 在实验室中,LMC-RES成功地穿过BBB,在神经元中积累,并通过Nrf-2/HO-1通路抑制氧化应激.
- 在AD小鼠中,LMC-RES降低了ROS,抑制了Aβ神经毒性,保护神经元,并显著改善了认知缺陷.
结论:
- LMC-RES有效地透到BBB,减轻氧化应激,并抑制Aβ聚合.
- 在阿尔茨海默病模型中,LMC-RES促进神经功能恢复.
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