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基于纳米技术的药物输送系统用于Honokiol:增强治疗潜力和克服局限性
Jing Yang1,2, Jinlu Shang1,2, Liuxuan Yang1,2
1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
International journal of nanomedicine
|November 29, 2023
概括
红 (HNK) 纳米输送系统通过克服不良的溶解性和生物可用性来增强其治疗潜力. 本综述详细介绍了HNK的各种纳米载体,探索应用和未来的挑战.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 红 (HNK) 是一种具有广泛药理作用的多,包括抗瘤和抗炎性质.
- 由于溶解性差,生物可用性低,以及新陈代谢快速,HNK的临床使用受到限制.
- 纳米技术为有效的HNK药物输送提供了解决方案.
研究的目的:
- 为了全面审查基于纳米技术的药物输送系统为Honokiol.
- 在过去15年中,评估用于HNK输送的不同纳米材料.
- 总结HNK纳米交付的最新应用,前景和挑战.
主要方法:
- 在PubMed,Scopus和Web of Science (2008-2023) 上进行了广泛的文献搜索.
- 关键词:"honokiol"",纳米技术"",药物输送系统".
- 选择了大约90篇相关文章进行审查.
主要成果:
- 已经开发了各种纳米载体,包括囊泡系统,纳米颗粒,聚合物微粒和纳米凝,用于HNK.
- 这些纳米配方显著提高了HNK的可溶性,生物可用性和循环时间.
- 在临床前研究中确定了HNK纳米输送系统的多种应用.
结论:
- 纳米技术对于克服HNK的局限性和提高其治疗疗效至关重要.
- 需要进一步的研究来优化HNK纳米输送系统的临床翻译.
- 未来的方向包括探索新型纳米载体和针对HNK的向传递策略.
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