与甲状腺眼病炎症和非炎症相相关的眼部表面疾病
Cinthia Minatel Riguetto1, Eduardo Buzolin Barbosa2, Camila Cristina Atihe2
1Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, São Paulo, Brazil.
Clinical ophthalmology (Auckland, N.Z.)
|November 29, 2023
概括
格雷夫氏病患者经常患有眼表面疾病,特别是干眼. 不活跃的甲状腺眼病显著增加了眼睛干燥的风险,而眼MMP-9表明活跃的甲状腺眼病.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 格雷夫斯病 (GD) 可以导致甲状腺眼病 (TED),影响眼睛.
- 目表面疾病 (OSD),包括干眼疾病 (DED),在GD患者中很常见.
- 了解GD,TED和DED之间的关系对于患者管理至关重要.
研究的目的:
- 评估眼表面疾病 (OSD) 和干眼疾病 (DED) 参数在患有格雷夫斯病 (GD) 的患者中.
- 在患有GD和甲状腺眼病 (TED) 的患者中研究撕裂矩阵金属蛋白酶9 (MMP-9) 的作用.
- 区分TED和没有TED的GD患者中的DED亚型.
主要方法:
- 包括17个活跃的TED,16个不活跃的TED,16个没有眼科病的GD和16个健康的对照.
- 评估的患者使用临床活性评分 (CAS),眼镜测量,定性痕MMP-9,OSDI,眼睛染色,希尔默测试,美图,膜高度,结膜高血和非侵入性膜破裂时间.
- 将DED分类为水性眼缺乏症,梅博米腺功能障碍 (MGD) 和混合干眼.
主要成果:
- 不活跃的TED是DED的重要危险因素 (OR 14,p=0.0047),患病率为87.5%,对照组为33.3% (p=0.0113).
- 与对照组 (6.7%,p=0.0273) 相比,非活动TED患者 (62.5%) 的梅博米腺功能障碍 (MGD) 患病率更高.
- 在活跃的TED中,定性MMP-9的阳性频率更高 (p < 0.0001),结膜发红在活跃的TED中高于没有眼科病的GD (p = 0.0214).
结论:
- 格雷夫斯病患者表现出高频率的眼表变化和DED,特别是那些没有活动TED的患者.
- 眼MMP-9阳性与活跃的TED有关,这表明它在眼科病的早期炎症阶段的作用.
- 不活跃的TED是导致GD患者DED的重要因素.
相关概念视频
Glaucoma: Overview
592
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
592
Angle Closure Glaucoma: Treatment
515
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
515
Open Angle Glaucoma: Treatment
456
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
456
Accessory Structures of the Eye
1.6K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.6K
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K


