重复静脉内注射对玻璃眼光谱疾病的影响
Rodrigo Vilares-Morgado1,2, Vera Correia3, Ana Margarida Ferreira1
1Department of Ophthalmology, Centro Hospitalar e Universitário de São João, Porto, Portugal.
Clinical ophthalmology (Auckland, N.Z.)
|November 29, 2023
概括
针对玻璃眼光谱疾病 (GSD) 的重复静脉内注射 (IVI) 并没有加速玻璃眼病的进展. 在注射和未注射的眼睛中,视网膜神经纤维层的厚度损失类似,这表明IVI对玻璃眼患者的安全性.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 视网膜成像 视网膜成像
背景情况:
- 玻璃眼光谱疾病 (GSD) 需要持续的管理.
- 用抗血管内皮生长因子 (抗VEGF) 药物进行静脉内注射 (IVI) 是常见的治疗方法.
- 重复的IVI对眼病进展的影响尚未完全理解.
研究的目的:
- 为了调查反复内注射 (IVI) 与抗VEGF药物是否加快了GSD眼睛的玻璃眼病进展.
- 为了比较注射眼睛和未注射眼睛之间的视网膜神经纤维层 (RNFL) 厚度变化.
主要方法:
- 对34名双边GSD患者进行了回顾性纵向研究.
- 纳入标准:一个眼睛≥8个IVI,至少12个月间隔≥2次RNFL厚度测量 (SD-OCT).
- 使用线性混合效应模型进行分析,以比较RNFL变化和眼内压力 (IOP) 变化.
主要成果:
- 在注射眼和未注射眼之间,RNFL厚度变化率没有显著差异 (-1.18±1.93微米/年与-1.07±0.98微米/年).
- 较高的基线RNFL厚度预测了注射眼睛中较大的RNFL损失.
- 两组之间绝对IOP变化没有显著差异;在两组中都增加了对玻璃眼的药物使用.
结论:
- 重复的静脉内注射 (IVI) 似乎没有加快GSD眼睛的玻璃眼病进展.
- 需要进行更多的随访期的进一步研究来证实这些发现.
- 这项研究表明IVI对眼病进展的潜在安全性.
相关概念视频
01:25Glaucoma: Overview
592
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
592
01:27Open Angle Glaucoma: Treatment
456
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
456
01:28Angle Closure Glaucoma: Treatment
515
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
515