低血清水平和长期毒性对甲状腺素. 案例报告案例报告
Ibtisam Musameh1, Faten Al-Bakri1, Asmaa Ezzeldin2
1Emergency Department, Hamad General Hospital, Qatar
Qatar medical journal
|November 29, 2023
概括
慢性甲状腺素 (MTX) 毒性从低剂量每日摄入可能发生由于管理错误. 这一案例凸显了识别累积剂量和潜在药物相互作用的重要性,以评估毒性风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床毒理学 临床毒理学
背景情况:
- 甲甲酸 (MTX) 是一种具有抗增殖和抗炎作用的叶酸对手,用于各种免疫和增殖性疾病.
- MTX毒性是一个重大问题,急性毒性可根据剂量预测,但慢性毒性缺乏特定的预测因素.
- 从高剂量瘤学到低剂量非瘤学指示的MTX使用的转变导致了剂量错误和毒性报告的增加.
研究的目的:
- 报告由于药物管理错误导致的慢性甲状腺素毒性病例.
- 强调需要更好地了解和预防低剂量MTX毒性.
- 强调累积剂量和药物相互作用在评估MTX毒性风险方面的重要性.
主要方法:
- 一个66岁的女性患者的病例报告,她无意中每天服用10毫克MTX,持续一个月.
- 测量了血清MTX水平,并在出现毒性症状时开始用叶酸治疗.
- 终止了MTX治疗,患者的病情得到改善.
主要成果:
- 由于每天服用MTX而不是处方的间歇性低剂量,患者出现了慢性毒性症状.
- 评估了血清MTX水平,用叶酸治疗导致改善.
- 该案提供了关于累积剂量和摄入时间的详细信息,这些信息往往缺乏文献.
结论:
- 低剂量甲状腺素的慢性毒性需要进一步调查,以指导风险评估和治疗开始.
- 确定最低总累积剂量可能有助于评估毒性风险.
- 实施安全措施以防止药物管理错误对于MTX安全至关重要.
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