在prodromal Lewy体疾病中尾缩的特征
Alice Galli1,2,3, Andrea Pilotto1,2,3, Benedetta Chiarini1
1Neurology Unit Department of Clinical and Experimental Sciences University of Brescia Brescia Italy.
Alzheimer's & dementia (Amsterdam, Netherlands)
|November 29, 2023
概括
头和后部区域的结构性大脑变化是勒维体痴呆症 (DLB) 的早期指标. 这些变化存在于前进性DLB (p-DLB) 中,并且随着疾病的进展而恶化.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 痴呆症研究 痴呆症研究
背景情况:
- 患有莱维体 (DLB) 的痴呆症通常表现为顶部,部和部缩.
- 对于前体性DLB (p-DLB) 中的大脑结构变化的有限理解.
研究的目的:
- 评估p-DLB中的结构性大脑变化与健康对照 (HC) 和患有莱维体痴呆症 (DLB-DEM) 相比.
主要方法:
- 42名DLB患者 (20名p-DLB,22名DLB-DEM) 和27名HC患者的3特斯拉MRI扫描.
- 灰色物质体积和皮质厚度的voxel-wise分析.
主要成果:
- 在p-DLB和DLB-DEM中减少了尾和后面的顶及顶体积和厚度.
- 尾部缩在区分p-DLB和HC方面比岛屿缩更有效.
- 尾部缩与从p-DLB到DLB-DEM增加的前损伤相关.
结论:
- 尾和后部结构变化是DLB连续性的早期标志物.
- 这些变化与广泛的缩模式相关.
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