通过对测试系统与化学相互作用的基于omics的表征来推进化学安全评估
Giusy Del Giudice1,2,3,4, Giorgia Migliaccio1,2,3, Nicoletta D'Alessandro1,2,3
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Frontiers in toxicology
|November 29, 2023
概括
将omics数据集成到体外试验中可以提高化学安全评估. 这种方法提供了化学-生物相互作用的整体观点,提高了替代测试方法的实际相关性.
科学领域:
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
- 生物技术是生物技术.
背景情况:
- 化学品安全评估对于人类健康和环境保护至关重要.
- 传统的动物试验正在被以3R (减少,改进,替代) 原则为指导的体外试验方法所取代.
- 目前的体外试验方法往往缺乏全面的分子表征,限制了它们在现实世界中的适用性.
研究的目的:
- 要突出详细的体外试验系统特征的重要性.
- 展示omics数据如何改善替代化学安全测试方法的开发.
- 强调在毒理学中需要一个整体的化学-生物相互作用视角.
主要方法:
- 审查当前的体外试验策略和不良结果路径框架.
- 讨论应用omics数据 (基因组学,蛋白质组学,代谢组学) 进行测试系统的表征.
- 分析了两个相关的安全评估场景,以说明基于omics的方法的好处.
主要成果:
- 对于准确的毒理学评估,对体外试验系统的仔细表征至关重要.
- 奥米克斯数据提供了对生物系统对化学物质暴露的反应的更深入的理解.
- 数据驱动的,基于omics的方法提高了体外安全评估的预测能力和上下文化.
结论:
- 利用omics数据是推进化学安全评估体外方法的关键.
- 对化学生物相互作用的整体理解对于开发强大的替代测试策略至关重要.
- 未来的体外试验方法应该包括全面的分子分析,以提高现实世界的相关性.
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