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目前关于神经退行性疾病的体外模型的进展

Inês Pereira¹, Maria J Lopez-Martinez^1,2,3, Josep Samitier^1,2,3

¹Nanobioengineering Group, Institute for Bioengineering of Catalonia, Barcelona Institute of Science and Technology, Barcelona, Spain.

Frontiers in bioengineering and biotechnology

|November 29, 2023

概括

探索神经退行性疾病的先进体外模型至关重要. 这些模型,包括使用诱导多能干细胞 (iPSC) 的有机体和芯片上的器官,为药物发现提供了更好的人体组织模仿.

科学领域:

神经科学是一个神经科学.
生物技术是生物技术.
干细胞研究干细胞研究

背景情况:

神经退行性疾病由于神经组织的复杂性和难以接近,缺乏明确的原因和治疗方法.
现有的体内动物模型有局限性,与人类组织有显著差异.
越来越需要先进的体外模型来更好地研究这些复杂的疾病.

研究的目的:

批判性地审查用于研究神经退行性疾病的体外模型的演变.
要突出微流体平台和3D细胞培养的进步.
强调诱导多能干细胞 (iPSCs) 在模仿神经组织中的作用.

主要方法:

对神经退行性疾病体外模型的当前文献的综述.
对微流体平台和芯片器官技术的分析.
诱导多能干细胞 (iPSCs) 的评估,用于疾病建模.

主要成果:

3D细胞培养模型,如有机体和芯片器官,代表了尖端技术.
诱导多能干细胞 (iPSCs) 对于创建模拟健康和患病神经组织的模型非常有价值.
微流体平台增强了体外模型的能力.

结论:

先进的体外模型,特别是3D培养和基于iPSC的系统,对于理解神经退行性疾病至关重要.
这些模型为病理状况提供了人类神经环境的改进模拟.
这些模型的进一步开发将有助于神经退行性疾病研究和药物发现.

关键词:

在体外3D模型中的3D模型.生物打印是一种生物打印技术.iPSC细胞培养的细胞培养.微流体装置是一种微流体装置.神经退行性疾病的神经退行性疾病

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