基线BMI与第一发精神分裂症的临床症状改善有关:一项纵向研究
Xiaofang Chen1, Yong Fan2, Wenchao Ren2
1Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China.
Frontiers in pharmacology
|November 29, 2023
概括
在患有第一发精神分裂症 (SZ) 的患者中,较高的基线体重指数 (BMI) 与抗精神病治疗后负面症状的改善较差有关. 这一发现表明BMI影响早期精神分裂症治疗结果.
科学领域:
- 精神病学是一个精神病学.
- 临床神经科学 临床神经科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖症在精神分裂症 (SZ) 患者中非常普遍,超过了一般人口的比率.
- 已知抗精神病药物的体重增加与SZ患者的治疗反应相关.
- 基线体重指数 (BMI) 对SZ治疗益处的具体影响仍未得到充分研究.
研究的目的:
- 为了研究基线BMI和临床症状改善在第一次发作和药物先验SZ (FEMNS) 患者之间的关联.
- 确定基线BMI是否预测SZ早期抗精神病药物的治疗反应.
主要方法:
- 一组241名FEMNS患者接受了Risperidone治疗12周.
- 用积极和消极综合征尺度 (PANSS) 评估症状严重程度.
- 身体质量指数 (BMI) 在基线和12周治疗后被测量.
主要成果:
- 里斯比里治疗导致FEMNS患者体重增加.
- 基线BMI显示12周后负症状的改善与负相关性 (r = -0.14,p = 0.03).
- 线性回归确定了基线BMI作为早期SZ中RISPERIDONE反应的独立预测因子.
结论:
- 基线BMI和精神分裂症负面症状的改善之间存在显著的关系.
- 较高的基线BMI可能表明,在接受Risperidone治疗的早期精神分裂症患者中,负面症状的反应较差.
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