患有传染性内心炎的患者的万科米辛相关急性损伤:一项大型回顾性队列研究
Pan Kunming1, Huang Ying2,3,4, Xu Chenqi2,3
1Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.
Frontiers in pharmacology
|November 29, 2023
概括
范科米辛相关的急性损伤 (VA-AKI) 在17%的传染性内心炎患者中发生. 风险因素包括对比剂和较长的万科米辛治疗,需要更密切的监测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 范科米辛是感染性内心炎 (IE) 的首要治疗方法.
- 范科米辛与毒性有关,但其对IE患者急性损伤 (AKI) 的影响尚不清楚.
- 这项研究调查了IE患者的菌素相关AKI (VA-AKI).
研究的目的:
- 确定IE患者VA-AKI的发病率,风险因素和预后.
- 为了确定与VA-AKI发展相关的特定患者特征和治疗参数.
主要方法:
- 一个大型的回顾性队列研究.
- 包括被诊断患有IE的成年患者接受万科米.
- 主要结果是VA-AKI的发展.
主要成果:
- 在435名注册IE患者中,VA-AKI的发生率为17.01%.
- VA-AKI的独立风险因素包括更高的BMI,更长的万科米辛持续时间,先前存在的CKD,ICU入院以及同时使用的放射性对比剂.
- 范科米辛品种 (Lai Kexin与Wen Kexin) 是一个保护因素;治疗>10.75天增加了VA-AKI风险.
结论:
- 在IE患者中VA-AKI发生率显著,略高于一般人群.
- 同时使用的对比剂在IE患者中显著增加了毒性风险 (2倍).
- 长期的万科米辛治疗 (>10.75天) 和对比剂使用需要更密切地监测功能和万科米辛水平.
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